Improved growth model for two-stage continuous cultures of Lactobacillus helveticus
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Keywords

continuous culture
growth
lactic acid fermentation
substrate limitation
unstructured models

How to Cite

1.
Bouguettoucha A, Balannec B, Nacef S, Amrane A. Improved growth model for two-stage continuous cultures of Lactobacillus helveticus. Electron. J. Biotechnol. [Internet]. 2010 Oct. 25 [cited 2024 Dec. 11];13(5):0-. Available from: https://www.ejbiotechnology.info/index.php/ejbiotechnology/article/view/v13n5-16

Abstract

An unstructured model for growth and lactic acid production during two-stage continuous cultures of Lactobacillus helveticus was previously developed. The Verlhust model was considered to describe growth kinetics. Production models was based on modified Luedeking-Piret expressions involving an inhibitory effect for the first stage (seed culture) and a nutritional limitation effect for the second stage (culture). To account for the decrease of the biomass concentration observed in the second stage, the dilution rate Dc was replaced by an exponential term of the dilution rate in the growth and product relations. Contrarily to the previous model, the important decrease of the biomass concentration observed at steady state in the second stage at high dilution rates, namely close to wash out, was correctly described by the new model. It also proved to satisfactory describes production data and volumetric productivity.

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