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Vol 12, No 2 (2009)
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Novel antiviral activity of dialdehyde starch | Song | Electronic Journal of Biotechnology
doi: 10.2225/vol12-issue2-fulltext-6
Electronic Journal of Biotechnology, Vol 12, No 2 (2009)

Novel antiviral activity of dialdehyde starch

Le Song, Caroline Cruz, Samuel R. Farrah, Ronald H. Baney



Abstract

A significant effort worldwide is being directed toward development of novel biocides against drug-resistant bacterial and viruses because of the significant potential human infection risks in the general population. We report here the discovery of a strong antiviral biocide, dialdheyde starch (DAS). Antiviral tests were carried out against three non-envelop viruses, including two bacterial viruses MS2 and PRD1, and one human virus Poliovirus. Dialdehyde starch aqueous suspensions were effective biocides against these three test viruses in a 1 hr exposure test. The antiviral activity was significantly enhanced in a four-hour exposure test, with maximum seven orders of magnitude reductions against MS2 and PRD1, and four-order reduction against Poliovirus. The antiviral activity of dialdehyde starch was found to be pH dependent, being more active in alkaline and acidic conditions than in neutral conditions.




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ISSN:  0717-3458

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