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Vol 58 (2022)
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Evaluation of miR-141-3p over-expression in ovarian cancer | Shi | Electronic Journal of Biotechnology
doi:10.1016/j.ejbt.2022.04.006
Electronic Journal of Biotechnology, Vol 58 (2022)

Evaluation of miR-141-3p over-expression in ovarian cancer

Lin Shi, Hao-Jia Sun, Jing-Jing Zeng, Zi-Qian Liang, Yun-Hua Lin, Su-Ning Huang, Jiang-Hui Zeng, Li Yang, Hao Chen, Jie Luo, Kang-Lai Wei



Abstract

Background: The expression of miR-141-3p in many malignant tumors has been verified. Nevertheless, the relationship between ovarian cancer and miR-141-3p remains undetermined. Therefore, further exploration is required.

Results: According to data from 100 samples, the final results of RT-qPCR showed that miR-141-3p was highly expressed in ovarian cancer. Furthermore, miR-141-3p was able to distinguish ovarian cancer cells from ovary tissues. The most significant Kyoto Encyclopedia of Genes and Genomes pathway, was regulation of lipolysis in adipocytes in ovarian cancer. The expression of PIK3R1 was negatively correlated with miR-141- 3p. PIK3R1 has a combing site with miR-141-3p.

Conclusions: This study examined the expression levels and mechanism of miR-141-3p in ovarian cancer for the first time. The results suggested that miR-141-3p may promote the occurrence of ovarian cancer by down-regulating PIK3R1.




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ISSN:  0717-3458

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