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Vol 17, No 4 (2014)
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One-pot synthesis of graphene-chitosan nanocomposite modified carbon paste electrode for selective determination of dopamine | Liu | Electronic Journal of Biotechnology
doi:10.1016/j.ejbt.2014.04.013
Electronic Journal of Biotechnology, Vol 17, No 4 (2014)

One-pot synthesis of graphene-chitosan nanocomposite modified carbon paste electrode for selective determination of dopamine

Chang Liu, Jing Zhang, Yifeng E, Jingli Yue, Lianshan Chen, Donghui Li



Abstract

Background: A simple, rapid, low-cost and environmentally friendly method was developed to determine dopamine (DA) in the presence of ascorbic (AA) and uric acid (UA) based on a novel technique to prepare a graphene-chitosan (GR-CS) nanocomposite and modify it on the surface of carbon paste electrode (CPE). For our design, CS acts as a media to disperse and stabilize GR, and then GR plays a key role to selective and sensitive determination of DA.

Results: Under physiological conditions, the linear range for dopamine was determined from 1.00 x 10-4 to 2.00 x 10-7mol/L with a good correlation coefficient of 0.9961 in the presence of 1000-fold interference of AA and UA. The detection limit was estimated to be 9.82 x 10-8 mol/L (S/N=3). In order to study the stability and reproducibility, GR/CS/CPE was suffered successive measurements in 10 times and then tested once a d for 30 d. The result exhibited 98.25% and 91.62% activities comparing with original peak current after 10-time measurements and 30-d store.

Conclusion: The GR/CS/CPE has wide linear concentration range, low detection limit, good reproducibility and stability, suggest that our investigations provide a promising alternative for clinic DA determination.




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ISSN:  0717-3458

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