Figure 4. Average displacements of the substrate and inhibitor compared with position of substrate in wild-type enzyme.

C128D-N, arginine in Asp 128Asn mutant;
C141H-F, arginine His 141Phe mutant;
C141H-N, arginine in His 141Asn mutant;
C141H-F*, lysine in His 141Phe mutant;
C141H-N*, lysine in His 141Asn mutant;
C141*, lysine in wild type enzyme.