Table 2. Kinetic parameters for CTX block of mSlo clones

 

Channel type

k off(x10-3 s-1)

k on (x106 s-1 M-1)

KD (nM)

n

mSlo

74 ± 7

10 ± 0.6

7.4

7

mSlo-GFP

82 ± 14

11 ± 1.3

7.6

5

rat skeletal muscle*

62 ± 3

7.0 ± 1.1

8.8

9


Association and dissociation rate constants of CTX, kon and koff, and the dissociation constant KD, were measured at + 30 mV on single maxi-K channels. Each value represents the mean ± SE of the number of measurements reported (n), each employing 100-246 blocking events of a single channel in a separate bilayer.

*(Stampe et al., 1994)

Supported by UNESCO / MIRCEN network
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