Figure 7. Concentration dependence of CTX Block of mSlo.
At each CTX concentration, records were taken for 25-45 min, and mean dwell times were calculated for the active (bursts, solid circles) state and the blocked (open circles) state. Each point represents the mean dwell time (± s.e.m.) calculated from 3 to 5 separate single channels. Each line represents a linear fit of the data. Note that the point at which the lines cross is equal to the KD (7.4 nM for mSlo).