|
| Table 1. Commonly used protecting groups for the side chains in tBoc/Bzl and Fmoc/tBu strategies. |
|
Amino acid |
Side chain group |
Protecting group |
|
|
Fmoc strategy |
t-Boc strategy |
||
| serine |
R-OH |
t-butyl |
benzyl (Bzl) |
| threonine |
R-OH |
t-butyl |
benzyl (Bzl) |
| tyrosine |
Ph-OH |
t-butyl |
2-Br-benzyloxycarbonyl |
| cysteine |
R-SH |
trityl |
p-methylbenzyl |
| aspartic acid |
R-COOH |
t-butyl |
benzyl |
| glutamic acid |
R-COOH |
t-butyl |
benzyl |
| lysine |
R-NH2 |
t-butyloxycarbonyl |
2-Cl-bezyloxycarbonyl |
| arginine |
R-NH-C(=NH)-NH2 |
2,2,5,7,8.pentamethyl- croman-6-sulfonyl |
tosyl |
| histidine
|
|
trityl |
tosyl 2.4-dinitrophenyl |
| tryptophan
|
|
t-butyloxycarbonyl |
formyl |
|
|
