Biotechnology of Human Disorders
EJB Electronic Journal of Biotechnology ISSN: 0717-3458 Vol.1 No.2, Issue of August 15, 1998.
© 1998 by Universidad Católica de Valparaíso -- Chile

Ion pumps as targets for therapeutic intervention: Old and new paradigms

David S. Perlin
Public Health Research Institute, New York, NY 10016
Tel.: 212 578-0820

Keywords: ion pumps, therapeutics, omeprazole, digoxin, antifungal.


The development of an effective target for therapeutic intervention remains a critical part of the drug discovery process. One such target class is the P-type ion translocating ATPases, which include the Na+,K+-ATPase of cardiac cells and the H+,K+-ATPase of gastric parietal cells. These enzymes serve as selective targets for digoxin and omeprazole, which are used to treat heart disease and gastrointestinal ulcers, and are two of the leading prescribed therapeutics worldwide. It is the exquisite selectivity that can be achieved between family members that continues to make the P-type enzymes desirable targets for developing new therapeutics including a new generation of antiulcer therapeutic and a new class of antifungal therapeutic.

Supported by UNESCO / MIRCEN network
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