Electronic Journal of Biotechnology ISSN: 0717-3458
  © 2004 by Universidad Católica de Valparaíso -- Chile
Vol. 7 No. 3, Issue of December 15, 2004

Table 1. Cellular proteins involved in gene silencing.


Mutant name/organism

Possible roles


qde1/ Neurospora

sde1/ Arabidopsis

sgs2/ Arabidopsis

ego1/ C. elegans

  1. Synthesis of cDNA
  2. Amplification of dsRNA
  3. Signaling of methylation
  4. Development
  5. Viral defense


qde2/ Neurospora

rde1/ C. elegans

ago1/ Chlamydomonas

  1. Target PTGS to ribosomes
  2. Signaling of methylation
  3. Development


Rnase D-like

RNA helicase

qde3/ Neurospora

mut-7/ C. elegans

mut-6/ Chlamydomonas

  1. Unwinding dsRNA helicase
  2.  Transposon defense
  3. Ribonuclease

Coiled-coil protein

sgs3/ Arabidopsis

  1. Signaling methylation
  2. Viral defense

NMD proteins

smg2/ C. elegans

smg5/ C. elegans

smg6/ C. elegans

  1. ATPase helicase/RNA binding
  2. Dephosphorylation of SMG2


Nicotiana tobacum

  1. Suppression of PTGS
  2. Development

ago1, argonaute1; ego1, enhancer of glp-1; qde, quelling defective; rde, RNA interference deficient; rgs-Cam, regulator of gene silencing calmodulin-like protein; sde, silencing defective; sgs, suppressor of gene silencing

Supported by UNESCO / MIRCEN network