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Electronic Journal of Biotechnology ISSN: 0717-3458
  © 2011 by Universidad Católica de Valparaíso -- Chile
Vol. 14 No. 2, Issue of April 15, 2011
 

Table 3. Comet assay of genomic DNA in KB cells untreated and treated with compound 3 at different concentrations for 72 hrs. Stock solution of compounds was prepared in DMSO and the final concentration of this solvent was kept constant at 0.25%. Control cultures received DMSO alone.



Treatments

KB cells
TMOMa

Control

93 ± 3.4

Compound 3
6.25 µM

1096 ± 18*

12.5 µM

1320 ± 36*

25 µM

2765 ± 31*

aTMOM= tail moment expressed as the product of TD (distance between head and tail) and TDNA. The values are the mean ± SD of three experiments performed in quadruplicate. *Significant vs. control untreated cells (p < 0.001).