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Electronic Journal of Biotechnology ISSN: 0717-3458
  © 2011 by Universidad Católica de Valparaíso -- Chile
Vol. 14 No. 2, Issue of April 15, 2011
 

Table 1. Cell growth inhibition, assayed using MTT test, of KB cells untreated and treated with jasmonic acid (JA) and compounds 1-3 at different concentrations for 72 hrs. Doxorubicin was used as a positive control. Stock solution of compounds was prepared in DMSO and the final concentration of this solvent was kept constant at 0.25%. Control cultures received DMSO alone.



Treatments

KB cells
IC50 a(µM)

 Doxorubicin

9.11 ± 0.4

 Compound JA

25.31 ± 0.9

 Compound 1

17.07 ± 0.4

 Compound 2

12.75 ± 1.1

 Compound 3

9.27 ± 0.8

aResults are expressed as IC50 values (µM) ± SD. The IC50 value, relative to untreated control, represents the concentration that inhibited cell vitality by 50%. Each value represents the mean ± SD of three experiments, performed in quadruplicate.