Figure 9. The solution space of metabolic
networks. In the
three-dimensional unconstrained flux space of a hypothetical network, fluxes
can assume any value.
a) Solutions obtained by restrictions
stoichiometry, enzymatic limitations or the balance of mass, then the feasible
solution space is reduced to a cone;
b) Restrictions by using an objective
function, such as maximizing biomass accumulation, can identify a coordinate
(set of flux values) on an of the feasible flux cone (red point). (adapted
from Lanzeni et al. 2008).